China (Mainland)
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Nordihydroguaiaretic acid NDGA 500-38-9 CAS NO.500-38-9
- Min.Order: 5 Gram
- Payment Terms: L/C,D/A,D/P,T/T,
- Product Details
Keywords
- masoprocol
- INSM-18
- INSM18
Quick Details
- ProName: Nordihydroguaiaretic acid NDGA 500-38-...
- CasNo: 500-38-9
- Molecular Formula: C18H22O4
- Appearance: solid powder
- Application: Pharmaceuticals
- DeliveryTime: in 7 days
- PackAge: Packing according to customer's requir...
- Port: Shanghai,Hangzhou
- ProductionCapacity: 5000 Gram/Month
- Purity: 98% min
- Storage: Keep containers tightly closed. Store ...
- Transportation: Conventional transport
- LimitNum: 5 Gram
- Exact Mass: 302.15
- Molecular Weight: 302.365
- PSA: 80.92
- LogP: 3.5664
- Target: 5-Lipoxygenase; Autophagy
- Pathway: Autophagy; Metabolic Enzyme/Protease
- Solubility: DMSO: ≥ 43 mg/mL
Superiority
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-known enterprises and research institutions. To the workshop from the laboratory-scale production, with good conditions for the custom synthesis can be achieved from gram to ton-class custom synthesis services.
1. Risk-free guarantee, 30days refund.
2. Custom synthesis service between grams to hundred kilograms.
3. Excellent After-sale service
4. The packing also can be according the customers` requirment.
5. Any question will be replied within 24 hours.
FAQ
Q1. How does your factory control quality
All the raw material purchasing and production quality control are strictly following the ISO9001. Besides, the full-featured detection equipment and GMP quality management system to provide the strongest guarantee for high quality product. We can provide our customers the detailed test report for the quality evaluation before the sample.
Q2: How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q3: How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q4: Can you give me a discount price
Sure,It depend on your qty.
Q5: How is Your MOQ for an order
Usually, the MOQ for most product is 1kg,and we also accept the sample order 100g,500g or others.
Details
Nordihydroguaiaretic acid, also known as NDGA and masoprocol, is a naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. NDGA directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, NDGA inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrines; it may prevent leukocyte infiltration into tissues and the release of reactive oxygen species and, at higher concentrations, may also inhibit cyclooxygenase.
Properties:
Appearance & Physical State: white to off-white powder
Density: 1.241 g/cm3
Melting Point: 184-189ºC
Boiling Point: 526.5ºC at 760 mmHg
Flash Point: 247.8ºC
Refractive Index: 1.626
Stability: Stable. Incompatible with oxidizing agents.
Storage Condition: Freezer (-20ºC)
Taizhou Crene Biotechnology Co., Ltd is a high-tech manufactory, which is committed to producing high quality pharmaceutical intermediates, promoting innovation in API technology and provide customized services for global pharmaceutical companies, dedicates itself on research, develop and industrialize of high-end intermediates & API.
Our new plant including 500㎡ analysis laboratories equipped with HPLC, LC-MS, GC and other analytical facilities, one pilot and four mass production workshop, the total reaction capacity can reach 35000L which can meet commercial production demands from kilos to hundreds of tons, is perfect for analysis and production.
Our products are highly praised by global customers as we are Closed cooperation with domestic pharmaceutical companies, with International market of India by intermediates, South American by APIs and actively develop the European and American market, cooperated with customers to DMF registration.
1. By "the suggested storage temperature is at -20℃", we mean you should keep the left compound at -20℃ after you open the vial and could not use the compound out at one time.
2. Most of our compounds are in dry powder and of very good stability, so it is safe during the transition at room temperature and it could last for 1-2 weeks and even more.
3. For some specific sensitive compounds, we will ship them with dry ice or blue ice.