China (Mainland)
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Rapamycin Sirolimus 53123-88-9 CAS NO.53123-88-9
- Min.Order: 10 Gram
- Payment Terms: L/C,D/A,D/P,T/T,
- Product Details
Keywords
- WY-090217
- AY 22989
- Rapamune
Quick Details
- ProName: Rapamycin Sirolimus 53123-88-9
- CasNo: 53123-88-9
- Molecular Formula: C51H79NO13
- Appearance: White to off-white solid powder
- Application: Pharmaceuticals
- DeliveryTime: in 7 days
- PackAge: Packing according to customer's requir...
- Port: Shanghai,Hangzhou
- ProductionCapacity: 5000 Gram/Month
- Purity: 98% min
- Storage: Keep containers tightly closed. Store ...
- Transportation: Conventional transport
- LimitNum: 10 Gram
- Grade: Pharma Grade
- Exact Mass: 913.555
- Molecular Weight: 914.172
- PSA: 195.43
- LogP: 6.1185
- Target: mTOR
- Pathway: PI3K/Akt/mTOR
- Solubility: DMSO: ≥ 28 mg/mL
Superiority
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-known enterprises and research institutions. To the workshop from the laboratory-scale production, with good conditions for the custom synthesis can be achieved from gram to ton-class custom synthesis services.
1. Risk-free guarantee, 30days refund.
2. Custom synthesis service between grams to hundred kilograms.
3. Excellent After-sale service
4. The packing also can be according the customers` requirment.
5. Any question will be replied within 24 hours.
FAQ
Q1. How does your factory control quality
All the raw material purchasing and production quality control are strictly following the ISO9001. Besides, the full-featured detection equipment and GMP quality management system to provide the strongest guarantee for high quality product. We can provide our customers the detailed test report for the quality evaluation before the sample.
Q2: How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q3: How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q4: Can you give me a discount price
Sure,It depend on your qty.
Q5: How is Your MOQ for an order
Usually, the MOQ for most product is 1kg,and we also accept the sample order 100g,500g or others.
Details
Sirolimus, also known as rapamycin, is a natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production.
Properties:
Appearance & Physical State: yellow solid
Density: 1.182 g/cm3
Melting Point: 183-185ºC
Boiling Point: 973.017ºC at 760 mmHg
Flash Point: 542.261ºC
Refractive Index: 1.55
Stability: Stable if stored as directed.
Storage Condition: -20ºC
Taizhou Crene Biotechnology Co., Ltd is a high-tech manufactory, which is committed to producing high quality pharmaceutical intermediates, promoting innovation in API technology and provide customized services for global pharmaceutical companies, dedicates itself on research, develop and industrialize of high-end intermediates & API.
Our new plant including 500㎡ analysis laboratories equipped with HPLC, LC-MS, GC and other analytical facilities, one pilot and four mass production workshop, the total reaction capacity can reach 35000L which can meet commercial production demands from kilos to hundreds of tons, is perfect for analysis and production.
Our products are highly praised by global customers as we are Closed cooperation with domestic pharmaceutical companies, with International market of India by intermediates, South American by APIs and actively develop the European and American market, cooperated with customers to DMF registration.
The suggested storage temperature shown on our website is at -20℃, but the package are usually shipped at room temperature, so you may feel confused and worry about the stability of the compounds, hope you could get relaxed after reading the following Packing Instructions:
1. By "the suggested storage temperature is at -20℃", we mean you should keep the left compound at -20℃ after you open the vial and could not use the compound out at one time.
2. Most of our compounds are in dry powder and of very good stability, so it is safe during the transition at room temperature and it could last for 1-2 weeks and even more.
3. For some specific sensitive compounds, we will ship them with dry ice or blue ice.