China (Mainland)
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Bosutinib 380843-75-4 CAS NO.380843-75-4
- Min.Order: 50 Gram
- Payment Terms: L/C,D/A,D/P,T/T,MoneyGram
- Product Details
Keywords
- SKI-606
- WAY-173606
- 3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-Methoxyphenyl)aMino]-6-Methoxy-7-[3-(4-Methyl-1-piperazinyl)propoxy]-
Quick Details
- ProName: Bosutinib 380843-75-4
- CasNo: 380843-75-4
- Molecular Formula: C26H29Cl2N5O3
- Appearance: Pale yellow solid powder
- Application: Pharmaceuticals
- DeliveryTime: in 7 days
- PackAge: Packing according to customer's requir...
- Port: Shanghai,Hangzhou
- ProductionCapacity: 10 Kilogram/Month
- Purity: 99% min
- Storage: Keep containers tightly closed. Store ...
- Transportation: Conventional transport
- LimitNum: 50 Gram
- Exact Mass: 529.165
- Molecular Weight: 530.446
- PSA: 82.88
- LogP: 5.13918
- Target: Bcr-Abl; Src
- Pathway: Protein Tyrosine Kinase/RTK
- Solubility: DMSO: ≥ 46 mg/mL
Superiority
Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-known enterprises and research institutions. To the workshop from the laboratory-scale production, with good conditions for the custom synthesis can be achieved from gram to ton-class custom synthesis services.
1. Risk-free guarantee, 30days refund.
2. Custom synthesis service between grams to hundred kilograms.
3. Excellent After-sale service
4. The packing also can be according the customers` requirment.
5. Any question will be replied within 24 hours.
FAQ
Q1. How does your factory control quality
All the raw material purchasing and production quality control are strictly following the ISO9001. Besides, the full-featured detection equipment and GMP quality management system to provide the strongest guarantee for high quality product. We can provide our customers the detailed test report for the quality evaluation before the sample.
Q2: How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q3: How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q4: Can you give me a discount price
Sure,It depend on your qty.
Q5: How is Your MOQ for an order
Usually, the MOQ for most product is 1kg,and we also accept the sample order 100g,500g or others.
Details
Bosutinib, also known as SKI-606, is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Unlike imatinib, bosutinib inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis. Because of the dual mechanism of action, this agent may have activity in resistant CML disease, other myeloid malignancies and solid tumors. Abl kinase is upregulated in the presence of the abnormal Bcr-abl fusion protein which is commonly associated with chronic myeloid leukemia (CML). Overexpression of specific Src kinases is also associated with the imatinib-resistant CML phenotype.
Properties:
Appearance & Physical State: white powder
Density: 1.36
Melting Point: 116-120ºC
Boiling Point: 649.7ºC at 760 mmHg
Flash Point: 346.7ºC
Refractive Index: 1.651
Taizhou Crene Biotechnology Co., Ltd is a high-tech manufactory, which is committed to producing high quality pharmaceutical intermediates, promoting innovation in API technology and provide customized services for global pharmaceutical companies, dedicates itself on research, develop and industrialize of high-end intermediates & API.
Our new plant including 500㎡ analysis laboratories equipped with HPLC, LC-MS, GC and other analytical facilities, one pilot and four mass production workshop, the total reaction capacity can reach 35000L which can meet commercial production demands from kilos to hundreds of tons, is perfect for analysis and production.
Our products are highly praised by global customers as we are Closed cooperation with domestic pharmaceutical companies, with International market of India by intermediates, South American by APIs and actively develop the European and American market, cooperated with customers to DMF registration.
The suggested storage temperature shown on our website is at -20℃, but the package are usually shipped at room temperature, so you may feel confused and worry about the stability of the compounds, hope you could get relaxed after reading the following Packing Instructions:
1. By "the suggested storage temperature is at -20℃", we mean you should keep the left compound at -20℃ after you open the vial and could not use the compound out at one time.
2. Most of our compounds are in dry powder and of very good stability, so it is safe during the transition at room temperature and it could last for 1-2 weeks and even more.
3. For some specific sensitive compounds, we will ship them with dry ice or blue ice.